COVID 19 is rapidly spreading throughout the world. Several complications have been described which has been accompanying this infection. There have been few cases reported with autoimmune active haemolysis subsequently with COVID 19, most of them corresponding to Warm autoimmune haemolytic anemia. MRS.XX, 45 years old woman presented with complaints of generalised weakness, yellowish discoloration of skin for the last 5 days. She was incidentally found to be positive for COVID 19 after routine testing. On investigation the LFT disclosed unconjugated hyperbilirubinemia. Direct Coombe’s test was found to be positive when done after washing RBC’s and incubation. The patient was found to be positive for Heterozygous HbE phenotype. The patient was managed with blood transfusion and warming up the surrounding. Patient was discharged 4 days after stabilisation. This case gives positive result with conservative treatment with blood transfusion alone that to in presence of severe anemia for cold agglutinin disease presenting with COVID 19 in presence of HbE trait. This case affirms the relation between autoimmune haemolysis and COVID 19 infection. The association between HbE heterozygous with development of transient cold agglutinin disease in COVID 19 infection is yet to be ascertained.