Background: Shoulder pain, disability, and kinesiophobia are frequent yet under-examined complications in patients following coronary artery bypass graft (CABG) surgery. These factors may adversely impact rehabilitation outcomes and overall quality of life in post-CABG patients.

Objective: This study aimed to evaluate the presence and extent of shoulder pain, disability, and kinesiophobia in patients after CABG surgery, and to analyse the interrelationships between these variables.

Methods: A prospective cross-sectional observational study was conducted on 40 patients (aged 45–75 years) who underwent planned CABG surgery. Participants were assessed preoperatively and at two-month follow-up for shoulder pain and disability using the Shoulder Pain and Disability Index (SPADI) and for movement fear using the Tampa Scale for Kinesiophobia (TSK). Data were analysed using appropriate statistical tests to compare pre- and post-surgery outcomes and evaluate correlations among measures.

Results: The mean age of participants was 59.32 ± 8.76 years, with a predominance of males (85%). There was a significant increase in both SPADI pain and disability scores at follow-up (pain mean difference: -4.65 ± 4.88, p < 0.05; disability mean difference: -6.65 ± 6.32, p < 0.05), indicating increased shoulder pain and disability post-surgery. However, changes in TSK scores were not statistically significant (mean difference: -1.57 ± 5.30, p = 0.44), suggesting minimal change in kinesiophobia levels. Postoperative SPADI and TSK scores showed a moderate positive correlation, indicating that increased shoulder disability may be associated with heightened kinesiophobia.