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VOL. 7, ISSUE 2 (2025)
In-Vitro assessment of Anti-Alzheimer And Antioxidant Potentials of Jatropha integerrima Leaves
Authors
Gayathri S, Lokeswari P, Daniel Raj N, Prakash P N, Chantra I, Tamilarasi G
Abstract
The present study investigates the phytochemical composition and
bioactive potential of Jatropha integerrima leaf extract with a focus on
its anti-Alzheimer and antioxidant activities. Preliminary phytochemical
screening of the methanolic extract revealed the presence of flavonoids,
alkaloids, phenolic compounds, tannins, terpenoids, and saponins, which are known
to contribute to neuroprotective and free-radical scavenging properties. The
antioxidant activity was evaluated using in-vitro assays such as DPPH
and hydrogen peroxide radical scavenging, demonstrating significant
dose-dependent inhibition comparable to standard antioxidants. The
anti-Alzheimer potential was assessed through acetylcholinesterase (AChE) and
studies, indicating notable enzyme inhibitory activity suggestive of
cholinergic pathway modulation. These findings highlight J. integerrima
leaves as a promising source of natural compounds with potential therapeutic
applications in managing oxidative stress and neurodegenerative disorders such
as Alzheimer’s disease.
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Pages:89-94
How to cite this article:
Gayathri S, Lokeswari P, Daniel Raj N, Prakash P N, Chantra I, Tamilarasi G "<i>In-Vitro</i> assessment of Anti-Alzheimer And Antioxidant Potentials of <i>Jatropha integerrima</i> Leaves". International Journal of Medical Science and Research, Vol 7, Issue 2, 2025, Pages 89-94
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