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VOL. 7, ISSUE 2 (2025)
In silico evaluation of the anti-urolithiasis potential of Kalanchoe pinnata using Network Pharmacology and Molecular Docking approaches
Authors
Daniel Raj N, Chantra I, Dhanusu Raman N, Hema G, Prakash PN, Tamilarasi G
Abstract
Urolithiasis, a multifactorial disorder characterized by the formation
of renal calculi, remains a persistent global health challenge. The present
study explored the anti-urolithiasis potential of Kalanchoe pinnata
through network pharmacology and molecular docking approaches.
Phytoconstituents were selected from literature and the IMPPAT database and
screened for ADME and drug-likeness properties using the SwissADME tool. Target
prediction and disease-associated gene identification were performed using
SwissTargetPrediction and GeneCards databases, respectively. The intersecting
targets were analyzed through STRING and Cytoscape to identify hub genes.
Functional enrichment analyses via Metascape revealed key pathways, including
PI3K-AKT, apoptosis, and oxidative stress regulation, linked to urolithiasis
pathogenesis. Molecular docking studies demonstrated that quercetin and
kaempferol exhibited strong binding affinities with hub proteins AKT1, BCL2L1,
CASP3, and MMP9, confirming their multi-target therapeutic potential. These
findings suggest that Kalanchoe pinnata exerts anti-urolithiasis effects
by modulating oxidative stress, inflammation, and apoptosis pathways, providing
a scientific basis for its traditional use in renal disorder management.
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Pages:83-88
How to cite this article:
Daniel Raj N, Chantra I, Dhanusu Raman N, Hema G, Prakash PN, Tamilarasi G "<i>In silico</i> evaluation of the anti-urolithiasis potential of <i>Kalanchoe pinnata</i> using Network Pharmacology and Molecular Docking approaches". International Journal of Medical Science and Research, Vol 7, Issue 2, 2025, Pages 83-88
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