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VOL. 7, ISSUE 2 (2025)
The physiochemical effect of selenium levels on thyroid function in women with thyroid disorders
Authors
Hanan A Naef, Abeer A Kadhim
Abstract
Background: The main function of the thyroid gland is to control the rate of
metabolism. Thyroid problems are a variety of disorders that may lead to an
imbalance in the secretion of thyroid hormones such as (T4, T3) in addition to
(TSH) and may eventually lead to thyroid tumors. Selenium plays a major role in
the physiology and function of the thyroid gland, as the thyroid gland contains
large amounts of selenium in the form of selenocysteine, which is an amino acid
specifically incorporated into selenoproteins. In this study, the diagnosed
groups were divided equally into four groups, with 20 samples for each group of
women. One of these groups was the control group. Selenium deficiency was found
to lead to thyroid dysfunction. The average concentration of the hormone (TSH)
in the hyperthyroid group was found to have dropped sharply, with a significant
difference of 0.13 mIU/mL from the normal level of 2.42 mIU/mL. Thyroxine (T4)
secretion increased to 117.5 pmol/L, with a significant difference from the
normal level. Triiodothyronine (T3) concentration also increased from 1.6
pmol/L to 1.97 pmol/L. These differences in the levels of these hormones are
due to the decrease in selenium levels to 110.05 μg/L, compared to the normal
level of selenium, which is 134.5. (μg/L), while the hypothyroidism group led
to a selenium deficiency to 98.45 (μg/L), a significant increase in the serum
TSH level from the normal state, to 9.845 (mIU/mL), and a clear decrease in the
secretion of the hormone (T4) in this group at a rate of 91.35 (pmol/L) in the
control group to 77.05 (pmol/L), and a decrease in the hormone (T3) from 1.6
(pmol/L) in the control group to a rate of 1.4 (pmol/L). The goiter group
witnessed a sharp drop in the level of selenium, reaching approximately 50% of
the normal limit, as it recorded 70.80 (μg/L), which may be the main reason for
the goiter, with an approximate stability in the levels of the thyroid hormones
(T4) and (T3), and an increase in (TSH) in this group at a concentration rate
of 3.18 (mIU/mL) above the normal level. All of these results lead to a general
disturbance in thyroid function and hormone levels due to selenium deficiency.
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Pages:31-34
How to cite this article:
Hanan A Naef, Abeer A Kadhim "The physiochemical effect of selenium levels on thyroid function in women with thyroid disorders". International Journal of Medical Science and Research, Vol 7, Issue 2, 2025, Pages 31-34
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