Background: Chronic musculoskeletal pain disorders (CMPDs) are among the leading causes of disabilities across populations, resulting in high social and financial burden. This persistent pain condition may include the central sensitization (CS) phenomenon, which may be associated with severity of pain and quality of life that may be taken into account in CMPD treatment. Objective: The aim of the study was to explore association of CS with pain intensity and quality of life. Methods: In present cross-sectional study total of 185 gujarati participants aged 18-75, suffering from several CMPDs were included. CS symptoms were measured with the Gujarati Version of the CSI, pain intensity was measured by VAS and quality of life was measured by WHOQOL BREF Gujarati version. Statistical analysis was done by using SPSS 15 version. Spearman’s rank correlation coefficient test, Mann Whitney U test and Kruskal wallis test were applied for co-relation and between group comparisons respectively. Significance level was set at p<0.05. Results: There were statistically significant moderate positive correlation exists between CSI score and VAS score (Rho = 0.46, P = <0.001) and also there was statistically significant moderate negative correlation exist between CSI score and WHOQOL score (Rho = -0.60, P = <0.001). Conclusion: There is moderate association exist between CSI score with pain intensity and quality of life. In light of these results, it is recommended that clinicians supplement their assessment with the CSI in CMPDs for improved decision-making during treatment.