Background: Acute cholecystitis is a syndrome of symptoms such as upper quadrant pain, fever, and leukocytosis associated with inflammation of the gallbladder. Complications of acute cholecystitis include gallbladder gangrene or perforation, which can be life-threatening Case: A 34 years old woman, came to the ER with complaints of abdominal pain. On examinations we found positive Murphy sign, leucocytosis, and multiple stones in ultrasonography. We performed laparoscopic cholecystectomy within 72 hours after admission. The patient is hemodynamically stable. Conclusion: Cholecystectomy is the definitive therapy for stable patients with cholecystitis. Laparoscopic cholecystectomy is safer, thus must be the first approach in stable patients with cholecystitis and should be performed within 72 hours after admission.