Background: ischemic heart disease occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common presenting symptom is chest pain or discomfort. The principle of Multi slice CT is simple: in a conventional computed tomography, a collimated X-ray beam is emitted and data are collected by a row of detectors located on the other patient’s side. Aim of the study: The aim of the study is to evaluate the role of multi-slice CT coronary angiography in evaluation of patients with ischemic- coronary artery disease. Materials and Method: 40 patients were included in the study, from them 15 patients were excluded according to the Exclusion criteria and 25 patients were included according to the inclusion criteria (11 females (44%)& 14 male(56%). The age of the patients is 40-70 years.The study was done in Baqubah Teaching hospital/ Diyala/ Iraq from April 2021 till March 2022. Result: This study shows that among 15 patients with positive risk factors,8 patients (53%)had hypertension, 7 patients (46.6%) are smoker,8 patients (53%) had positive family history,6 patients (40%) had DM and 10 patients (66.6%) had hyperlipidaemia. The study shows that 7 patients (28.0%) of 25 patients are normal and no artery affected, 5 patients (20.0%) had one artery affected,5 patients (20.0%) had two arteries affected, 7 patients (28.0%) had three arteries affected and one patient (4.0%) had four arteries affected. The study shows there are 40 artery diseased. 17 (42.5%) of them are LAD, 13(32.4%) of them are RCA, 8 (20%) of them are LCX Conclusion: Noninvasive Multi slice CT is a valuable technique of high ability to detect coronary artery disease, estimate the degree of obstruction and characterize plaques which can be used as an initial step in the working up in patients with recently diagnosed ischemic heart disease and should be considered as an alternative to invasive diagnostic coronary angiography in this group of patients.