Abscess in the submandibular space is one of the most common deep neck abscesses. The submandibular space is a potential space in the neck consisting of the sublingual and submaxillary spaces separated by the mylohyoid muscle. It has been reported a 51-year-old male patient with a diagnosis of sinistra submandibular abscess with HIV infection stage IV pre HAART, in this patient previously had a history of lymphadenitis and a history of needle biopsy in the submandibular before the formation of an abscess in the sinistra submandibular, in this case it did not experience extension to the other potential spaces and on treatment showed improvement after incision drainage of the abscess and receiving medical therapy.