ARCHIVES
VOL. 4, ISSUE 1 (2022)
Multi organ damage of oxygen toxicity: A review article
Authors
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Soesilaningtyas, Rizki Nur Rachman Putra Gofur, Hernalia Martadila Putri
Abstract
Introduction: Oxygen is very useful for living things, especially humans. Oxygen functions for the body's metabolism and especially cell metabolism. But oxygen can also be toxic to the human body. This is known as oxygen toxicity. Oxygen toxicity is a condition that results from the harmful effects of inhaling molecular oxygen (O2) at high partial pressures, called as oxygen toxicity syndrome, oxygen intoxication, and oxygen poisoning. Discussion: Protocols to avoid hyperoxia exist in areas, when high pressure of oxygen is using for condition in medicine, some of emergency cases, some for rehabilitation condition. This protocol has resulted in an increased rarity of seizures due to oxygen poisoning, with lung and eye damage being primarily a problem in the management of preterm infants. This protocol has resulted in an increased rarity of seizures due to oxygen poisoning, with lung and eye damage being primarily a problem in the management of preterm infants. Moreover, oxygen could be toxic. The effects of oxygen poisoning can be classified by the organ affected, classified into three forms. First, The central nervous system, which is characterized by convulsions followed by stupor, occurs in a hyperbaric state. Second, pulmonary (lungs), characterized by difficulty breathing and pain in the chest, occurs when breathing high pressure oxygen for a long time. In the eye (retinopathic condition), characterized by changes in the eyes, occur when breathing high pressure oxygen for a long time. Conlusion: High concentrations of oxygen also increase the formation of other free radicals, such as nitric oxide, peroxynitrite, and trioxidane, which harm DNA and other biomolecules. Although the body has many antioxidant systems such as glutathione that guard against oxidative stress, these systems are eventually overwhelmed by very high concentrations of free oxygen, and the rate of cellular damage exceeds the capacity of the systems that prevent or repair them. Subsequently, cell damage and death then occurs.
Download
Pages:17-19
How to cite this article:
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Soesilaningtyas, Rizki Nur Rachman Putra Gofur, Hernalia Martadila Putri "Multi organ damage of oxygen toxicity: A review article ". International Journal of Medical Science and Research, Vol 4, Issue 1, 2022, Pages 17-19
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.