Introduction: Duhring disease is a autoimmune disease. The clinical manifestation may vary. Rash is polymorphic, mainly in the form of vesicles that are arranged in groups and symmetrical. Symptoms vary in intensity but many sufferers complain of a very severe itching, burning and burning sensation with predilection, especially on the extensor surface of the upper and lower limbs, elbows, knees, scalp, back of the neck (nape), back, shoulders, sacrum area and butt. The face and groin can also be affected. Discussion: Due to intense itching associated with the disease, patients often scratch the vesicles and this results in an appearance that appears only to be erosion and excoriation. Symptoms vary in intensity but many sufferers complain of intense itching, burning and intense burning. Which is often without precedence overt mainstream lesions within hours. Lesions that appear on the head, face, thighs and flexor area are seen in more severe cases. Pustules are very rare except when secondary infection occurs. Vesicles that arise especially if they are on the hands may be hemorrhagic. Lesions that appear and disappear continuously, will cause hypopigmentation and hyperpigmentation. Conclusion: The main lesions of dermatitis herpetiformis are clusters of erythematous papules, urticarial plaques or most commonly vesicles that appear in groups but may also appear in groups. Papu lovesicles 'herpetiformis' 3–6 mm in size with an erythematous base are characteristic of the disease, large bullae are rare.