Objectives: This study was to evaluate the effect of silver nitrate solution on bacterial load in the wound, rate of granulation tissue formation, time required for healing, skin graft uptake and side effect of topical silver nitrate dressing in diabetic foot ulcer patients. Methods: Detail history, clinical examinations and relevant investigations were performed to all diabetic foot ulcer patients. Silver nitrate solution was used for dressing of case group patients. whereas in control group dressing was done by 50% w/v povidone-iodine solution. Results: Data was analysed by using IBM SPSS version 26 software. Mean ± standard deviations was observed. Chi square test was applied. P value was taken less than or equal to 0.05 (p≤0.05) for significant differences. Conclusions: Elderly diabetic age group patients were prone to diabetic foot ulcer. Male was more preponderance than female. A significant beneficial effect was seen in dressing with silver nitrate solution in terms of bacterial load in the wound, rate of granulation tissue formation, time required for healing, skin graft uptake and side effect with respect to 50% w/v povidone-iodine solution dressing in diabetic foot ulcer patients. Hence, Silver nitrate solutions should be used for the management of wound healing in diabetic foot ulcer. It is a cost-effective option with better results.