Work stress is a problem facing human power everywhere with extensive impact on increased health risks in developing countries. Prolonged exposure to stress, results in debilitating chronic diseases that affect the wellbeing of the human power and reduce their productivity. Allostatic Load Index (ALI) is a measure that detects stress at its early stages and predicts individuals at high risk. The present perspective gives a brief account on types and consequences of stress in the working environment. It also describes the concept of allostasis, how ALI is calculated and the importance of Allostatic load assessment as a protective measure for the workforce general state of health.