Aim: The aim of the present study was to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in patients diagnosed with metabolic syndrome (MetS).

Methods: The study was conducted in the Department of Medicine. The study protocol was approved by local independent ethics committees. In this study, we had enrolled 400 patients with MetS. The study was conducted in accordance with the principles of the Declaration of Helsinki, International Council on Harmonization Good Clinical Practice (ICH GCP) guidelines, and Indian regulatory guidelines (Indian Council of Medical Research and Indian GCP guidelines).

Results: In this study, we had enrolled 400 patients with MetS. The baseline demographic characteristics of these patients are shown. Of all the enrolled patients, 120 (30%; 95% CI: 23.83-32.32) were diagnosed with TD (mean age (SD): 47.9 (10.96) years; mean BMI: 30 ± 4 94 kg/m2), with a higher prevalence among women compared to men (91 (75%) vs. 30 (25%)). Of the 400 MetS patients, overt hypothyroidism was reported in 78 (19.5%) patients and overt hyperthyroidism in 8 (2%) patients.