Background: Osteoarthritis (OA) is the most predominant chronic joint condition worldwide and a main source for impaired function and disability with huge treatment costs and financial weight. It is a typical degenerative disorder of the articular cartilage related with hypertrophic bone changes and the predisposing factors incorporate hereditary qualities, female sex, past injury, propelling age, and weight. In spite of late accomplishments in the knowledge of disease pathogenesis, the treatment is as yet a test and as opposed to the inflammatory joint infections, no disease modifying medications are right now accessible for OA. Aim: This review plans to give an overview of the present learning of pathophysiology and the available choices accessible for knee osteoarthritis including non pharmacological, pharmacological and surgical methodologies. Methods: Thorough literature checking was done and the information sources included PubMed, the Cochrane Collection, Web of Science, and the Physiotherapy Evidence Database from 1970 till date, and ClinicalTrials.gov and the procedures from the 2015 American College of Rheumatology yearly gatherings. Results and Conclusion: Osteoarthritis of the knee joint is brought about by an intricate interchange among catabolic and anabolic impacts of chondrocytes, which includes the whole joint. Conservative management choices ought to be executed including a blend of training, exercise and physiotherapy, weight reduction, analgesics and neutraceuticals. Treatment for knee osteoarthritis starts with conservative methods and advances to surgical treatment alternatives when conservative treatment falls flat. No demonstrated disease modifying agents for the treatment of knee osteoarthritis right now exist.