Background: Shock-wave therapy (SWT) and Ultrasonic Therapy (UST) are two commonly used methods in the treatment of lateral epicondylitis. In this study, the efficacy of these two methods was compared. Methods: The study was planned as a pre-post experimental study design. A total of 67 patients were enrolled. The patients were divided into two groups: group 1 received SWT (32 patients) and group 2 received UST (35 patients). Patients in group 1 underwent four sessions of ESWT twice every week. In each session, an SWT device at 10 Hz, 1500 pulses, and 1.8 bar pressure was used. Patients in group 2 used an Ultrasonic Therapy, Pulsed mode 50%, time 10 minutes, frequency 3MHz for 2 weeks. Patients were assessed for handgrip strength, pain at rest, pain while working, and quality of life. Data were collected before and after treatment (at weeks 2). A visual analog scale was used to evaluate pain at rest and while working, subscales of the SF36 Health Survey to evaluate quality of life. Results: In both SWT and UST groups, although there were considerably significant improvements (P<0.001) in the parameters evaluated (pain at rest and while working, handgrip strength, Patient-Rated Tennis Elbow Evaluation, Nirschl score, and SF36 subscales) were observed at 2 weeks compared to pretreatment values, there was no statistically significant difference between the two groups in terms of our evaluation parameters at the three time points (P<0.05). Conclusion: Both SWT and UST applications were found to yield significantly superior results when compared to pretreatment values. In comparison of the two groups, on the other hand, there was no statistically significant difference.