The search for antiepileptic agents with more selectivity and lower toxicity continues to be an area of investigation in medicinal chemistry. The mechanisms of action of the antiepileptic drugs (AEDs) consist in the blockade of voltage-dependent Na⁺ channels or T-type Ca⁺² channels, inhibition of glutamatergic transmission and facilitation of γ-aminobutyric acid (GABA) inhibitory neurotransmission.