Allium sativum or Garlic has been used as a culinary spice and medicinal herb and has been an important part of Indian Ayurveda and Traditional Chinese Medicine. Garlic and its has been used for numerous health benefits and use useful in treatments of various diseases, like common cold, cancer, antimicrobial and cardiovascular agent. Garlic is a good phytoantioxidant with powerful chemo-preventive properties against chemically-induced oxidative stress. The garlic oil showed defensive role of against Sodium nitrite (NaNO₂)-induced toxicities in metabolic and biochemical parameters in male albino rats. The NaNO₂ induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea, creatinine as well as hepatic AST and ALT level. However, garlic oil significantly decreased ALP activity, glycogen content, and renal urea and creatinine levels. Garlic oil also caused significant increase in lipid peroxidation, decrease in glutathione content and catalase activity in the liver and the kidney. However, uses of garlic oil showed a remarkable reduction in these abnormalities.